Karyopherin alpha 1

Karyopherin alpha 1 (importin alpha 5)

PDB rendering based on 2jdq.
Identifiers
Symbols KPNA1; IPOA5; NPI-1; RCH2; SRP1
External IDs OMIM600686 MGI103560 HomoloGene55642 GeneCards: KPNA1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 3836 16646
Ensembl ENSG00000114030 ENSMUSG00000022905
UniProt P52294 Q60960
RefSeq (mRNA) NM_002264.3 NM_008465.5
RefSeq (protein) NP_002255.3 NP_032491.2
Location (UCSC) Chr 3:
122.14 – 122.23 Mb
Chr 16:
35.98 – 36.04 Mb
PubMed search [1] [2]

Importin subunit alpha-1 is a protein that in humans is encoded by the KPNA1 gene.[1]

Recombination activating proteins RAG1 and RAG2 regulate and mediate V(D)J recombination, the process by which genes for immunoglobulins and T-cell receptors are generated. Several other ubiquitously expressed proteins are thought to be recruited in the recombination process. Among these are the genes affected in severe combined immune deficiency and genes involved in ds-DNA break repair. The protein encoded by this gene interacts with RAG1 and may play a role in V(D)J recombination[2]

Interactions

Karyopherin alpha 1 has been shown to interact with KPNB1[3][4] and UBR5.[5]

References

  1. ^ Cortes P, Ye ZS, Baltimore D (Sep 1994). "RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1". Proc Natl Acad Sci U S A 91 (16): 7633–7. doi:10.1073/pnas.91.16.7633. PMC 44456. PMID 8052633. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=44456. 
  2. ^ "Entrez Gene: KPNA1 karyopherin alpha 1 (importin alpha 5)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3836. 
  3. ^ Köhler, M; Speck C, Christiansen M, Bischoff F R, Prehn S, Haller H, Görlich D, Hartmann E (Nov. 1999). "Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import". Mol. Cell. Biol. (UNITED STATES) 19 (11): 7782–91. ISSN 0270-7306. PMC 84838. PMID 10523667. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84838. 
  4. ^ Percipalle, P; Clarkson W D, Kent H M, Rhodes D, Stewart M (Mar. 1997). "Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import". J. Mol. Biol. (ENGLAND) 266 (4): 722–32. doi:10.1006/jmbi.1996.0801. ISSN 0022-2836. PMID 9102465. 
  5. ^ Henderson, Michelle J; Russell Amanda J, Hird Samantha, Muñoz Marcia, Clancy Jennifer L, Lehrbach Gillian M, Calanni Sophina T, Jans David A, Sutherland Robert L, Watts Colin K W (Jul. 2002). "EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response". J. Biol. Chem. (United States) 277 (29): 26468–78. doi:10.1074/jbc.M203527200. ISSN 0021-9258. PMID 12011095. 

Further reading